Meth, lsd, and cocaine...
I'll never forget the day one of my co-workers showed up to work at my last job drugged up on meth and cocaine. He was scheduled to drive up to Wyoming and do pickups there all day but he was so messed up he couldn't even keep his balance. Thankfully he was given a "random" drug test and fired on the spot.
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http://whdh.com/news/police-trucker-drove-from-seattle-to-massachusetts-nonstop-fueled-by-drugs/