To be blunt ... If you're asking on a trucking forum about pros and cons for a business decision of this magnitude, you probably shouldn't be thinking about making such a decision.
I had a friend who worked for FedEx. He says routes tend to dry up quickly. You have to really investigate if it will last as long as you want/need. That's really the extent of my knowledge on this matter. I have an aversion to anything temporary, but maybe you know how to make it worth your while.
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I'm thinking about buying a FedEx route when I want to know the pros and cons beforehand if any of your guys can help me let me know.